In this paper, we introduce a novel predict-and-optimize method for profit-driven churn prevention. We frame the task of targeting customers for a retention campaign as a regret minimization problem. The main objective is to leverage individual customer lifetime values (CLVs) to ensure that only the most valuable customers are targeted. In contrast, many profit-driven strategies focus on churn probabilities while considering average CLVs. This often results in significant information loss due to data aggregation. Our proposed model aligns with the guidelines of Predict-and-Optimize (PnO) frameworks and can be efficiently solved using stochastic gradient descent methods. Results from 12 churn prediction datasets underscore the effectiveness of our approach, which achieves the best average performance compared to other well-established strategies in terms of average profit.

Powered by machine learning services in the cloud, numerous learning-driven mobile applications are gaining popularity in the market. As deep learning tasks are mostly computation-intensive, it has become a trend to process raw data on devices and send the neural network features to the cloud, whereas the part of the neural network residing in the cloud completes the task to return final results. However, there is always the potential for unexpected leakage with the release of features, with which an adversary could infer a significant amount of information about the original data. To address this problem, we propose a privacy-preserving deep learning framework on top of the mobile cloud infrastructure: the trained deep neural network is tailored to prevent information leakage through features while maintaining highly accurate results. In essence, we learn the strategy to prevent leakage by modifying the trained deep neural network against a generic opponent, who infers unintended information from released features and auxiliary data, while preserving the accuracy of the model as much as possible.

With ongoing developments and innovations in single-cell RNA sequencing methods, advancements in sequencing performance could empower significant discoveries as well as new emerging possibilities to address biological and medical investigations. In the study, we will be using the dataset collected by the authors of Systematic comparative analysis of single cell RNA-sequencing methods. The dataset consists of single-cell and single nucleus profiling from three types of samples - cell lines, peripheral blood mononuclear cells, and brain tissue, which offers 36 libraries in six separate experiments in a single center. Our quantitative comparison aims to identify unique characteristics associated with different single-cell sequencing methods, especially among low-throughput sequencing methods and high-throughput sequencing methods. Our procedures also incorporate evaluations of every method's capacity for recovering known biological information in the samples through clustering analysis.